|
Symbol Name ID |
Park7
Parkinson disease (autosomal recessive, early onset) 7 MGI:2135637 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hyposmia |
Blepharospasm |
Stroke |
Spasticity |
Bradykinesia |
Parkinsonism with favorable response to dopaminergic medication |
Tremor |
Postural tremor |
Resting tremor |
Depression |
Anxiety |
Panic attack |
Psychotic episodes |
Hallucinations |
Apathy |
Reduced social reciprocity |
Impulsivity |
Agitation |
Restless legs |
Cognitive impairment |
Dementia |
Frontal lobe dementia |
Short attention span |
Insomnia |
Hyperreflexia |
Brisk reflexes |
Dyskinesia |
Dystonia |
Leg dystonia |
Gait imbalance |
Postural instability |
Abnormal autonomic nervous system physiology |
| Disease(s) Associated with PARK7 | ||||||||||||||||||||||||||||||||
| cerebral infarction | ||||||||||||||||||||||||||||||||
| Parkinson's disease | ||||||||||||||||||||||||||||||||
| Parkinson's disease 7 |
| Mouse Phenotypes | nervous system phenotype |
increased susceptibility to dopaminergic neuron neurotoxicity |
abnormal substantia nigra pars compacta morphology |
abnormal locus ceruleus morphology |
abnormal striatum morphology |
loss of dopaminergic neurons |
neuron degeneration |
abnormal action potential |
absent long-term depression |
abnormal neurotransmitter uptake |
|
| Availability | Mouse Genotype | ||||||||||
| Park7Gt(XE726)Byg/Park7Gt(XE726)Byg | |||||||||||
| Park7tm1Dsp/Park7tm1Dsp | |||||||||||
| Park7tm1Shn/Park7tm1Shn | * | ||||||||||
| Park7tm1Tmd/Park7tm1Tmd | * | ||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/16/2024 MGI 6.23 |
|
|
|
||
Analysis Tools